Assessing Clinical Trial Results

Interpretation of clinical trial results

Evidence from clinical trials is fundamental to ethical medical practice. Along with patient preferences, circumstances, and clinical experience, it is central to effective clinical decision-making. Applying evidence to clinical questions requires filtering in the form of three questions: first, do the trial results reflect true effects of intervention, rather than artifactual ones (validity)? ...

Formulating Queries for Assessing Clinical Trial Eligibility

This paper introduces a system that processes clinical trials using a combination of natural language processing and database techniques. We process web-based clinical trial recruitment pages to extract semantic information reflecting eligibility criteria for potential participants. From this information we then formulate a query that can match criteria against medical data in patient records. ...

Systematic review protocol assessing the processes for linking clinical trial registries and their published results

INTRODUCTION Clinical trial registries are an important source of information for tracking clinical trials from their inception through to their reporting, and have been used to measure publication bias and outcome reporting bias. Our aim is to survey and quantify the processes that have been used to identify links between clinical trial registries and published trial reports in studies that re...

Assessing generalizability of trial results in general practice.

The gold standard for assessing treatment effects is the randomized clinical trial. Providers are fortunate to have a robust set of trials with .80 000 participants showing important benefits and reassuring safety of the non-vitamin K oral anticoagulants (NOACs) relative to warfarin for stroke prevention in atrial fibrillation (AF). 4 Based on the consistent findings of these trials, providers ...

Is withholding clinical trial results "research misconduct"?